Decreased liver density as a potential predictor of severe COVID-19: a retrospective cohort study

Background. To stratify the risk in patients with COVID-19, it is important to understand parameters that predispose a severe course. Following factors were described: age over 60 years, overweight, male gender, chronic diseases: hypertension, diabetes mellitus. Low liver density on computed tomography (CT) also considered as potential factor.
 Aim. evaluation whether low can be used predictor of COVID-19.
 Materials and methods. Retrospective single-center cohort study. Patients COVID-19 treated hospital setting, who underwent two CT scans thoracic organs dynamics, included. The divided into groups according severity course (groups moderate course, lethal outcome). Relation investigated was estimated using regression analysis.
 Results. 99 enrolled; 3 comparison formed (moderate-severe n=37, n=52, outcome n=8). All significantly differed C-reactive protein levels. According multivariate analysis, influenced by spleen ratio measured scan admission [odds 12.18 (95% confidence interval 1.6789.07); p=0.008].
 Conclusion. Reduced patient may novel coronavirus infection.